ABSTRACT
Background: Candida species is known as the most commonopportunistic yeast affecting the genitourinary tract. Thetriazoles are commonly used for the treatment of candidiasis.But the increasing resistance of Candida to different azolescreated a demand for newer drugs.Objective: Voriconazole is a second generation azoleantifungal agent that shows excellent in vitro activity against awide variety of yeast and moulds. This study was done toassess the therapeutic efficacy of Voriconazole in Fluconazoleresistant vaginal candidiasis.Material and Methods: This one-group pretest-posttest quasiexperiment was conducted in a specialized private chamber ofFaridpur, Bangladesh from January 2018 to July 2019. Vaginalcandidiasis was diagnosed by clinical features, microscopicexamination, culture and sensitivity of high vaginal swab.Voriconazole was used only in Fluconazole resistant vaginalcandidiasis.Results: During the study period, 568 patients were presentedwith vulvovaginitis. Among them, in 267 (47%) patients,Candida albicans were isolated. All patients were treated byFluconazole as first-line treatment. 160 (60%) of those patientsdid not improve clinically and were treated by Voriconazole.Success rate was 93% (149). Regarding side effects ofVoriconazole, transient visual disturbance occurred in 35% ofthe patients, nausea and vomiting in 20% of the patients.Conclusion: Due to wide species variety of Candida andincreasing resistance, Voriconazole may be the second linetreatment of vaginal candidiasis.
ABSTRACT
Objective: In this study our main aim is to evaluate the healingof peptic ulcer disease after eradication of helicobacter pyloriinfection in rural people Bangladesh.Methodology: This Prospective observational study wasconducted at tertiary hospital Dhaka district from Tertiarymedical college and hospital among 100 patients diagnosedcoming to the gastroenterology outpatient departmentaccording to inclusion and exclusion criteria was included inthe study.Result: In our study among 100 patients, most of the patientsbelong to 31-40 years age group, which was 37.78% and 57%were male and 43% were female. 15.07% patients hadduodenal ulcer and 21.09% had gastric ulcer for H. pyloripositive.18% patients were still positive for H.pylori aftereradication therapy.Conclusion: In conclusion, we can say that, prolonged Followup with upper GI endoscopy for additional period for recurrenceof ulcer should have been done for patients whose peptic ulcerdisease had resolved but could not attain H. pylori eradication.
ABSTRACT
Background: Dyslipidemia is one of the modifiable risk factorsof acute myocardial infarction which is caused by presence ofabnormal amount of lipid in blood.Objective: In this study our main goal is to evaluate the patternof dyslipidemia in patients of acute myocardial infarction andtheir treatment outcome in Bangladesh.Method: This cross-sectional prospective observational type ofstudy was conducted among 100 purposively selected patientsof acute myocardial infarction attended in CardiologyDepartment of tertiary hospital, for treatment to see theirpattern of dyslipidemia and treatment outcome during February2016 to February 2017. Study subjects were selected fromadmitted patient at emergency department and at in-patientdepartment of the Cardiology Department with acute coronarysyndrome. Fasting lipid profile in next morning of admissionwas done and assessed. Dyslipidemia was consideredaccording to ATP III guideline with Serum Total cholesterol >200 mg/dl, TG>150 mg/dl, LDL >100 mg/dl, HDL. Collectedinformation was checked repeatedly. Information was collectedby the researchers. Data was processed and analyzed byusing pc bases software system SPSS- 23 (Statistical Packagefor Social Science).Results: During the study, male patients were 58% higherthan female and most of them belongs to 51-60 years agegroup (38%).75% patients had dyslipidaemia and aftertreatment 57% patients got discharged.Conclusion: We can conclude that hypertriglyceridemia andhypercholesterolemia are the most prevalent dyslipidemia inpatients of acute myocardial infarction in Bangladesh. Furtherresearch, in particular longitudinal studies, is needed for betteroutcome.
ABSTRACT
Background: Cervical cancer is the second most commoncancer among women in Bangladesh where CIN is theforerunner. Visual inspection of cervix with acetic acid (VIA) isadopted as national cervical cancer screening programme inBangladesh. All positive VIA cases are evaluated bycolposcopy.Objective: This population-based study was conducted inFaridpur Medical College Hospital for 6 years (2013 - 2018) toevaluate the prevalence of CIN among the VIA positive casesand performance of the clinic for colposcopic management ofCIN.Materials and Methods: A total of 2102 VIA positive caseswere evaluated by colposcopy during the study period.International Federation of Cervical Pathology and Colposcopy(IFCPC) 2011 nomenclature was used for colposcopicdiagnosis. Diagnosed CIN were treated accordingly.Results: During the study period, 548 (26.1%) cases werecolposcopically diagnosed as CIN. Among them, 370 (65.5%)were low grade squamous intraepithelial lesion (CIN-I) and 178(32.5%) were high grade squamous intraepithelial lesion (CINII and III). Colposcopicaly diagnosed 237 (64.1%) of low gradesquamous intraepithelial lesion (LSIL) and 132 (74.2 %) of highgrade squamous intraepithelial lesion (HSIL) casesreceived treatment and histopathological confirmation.Treatment produces were used like thermocoagulation, LoopElectrosurgical Excision Procedure (LEEP), biopsy,hysterectomy and post treatment follow up.Conclusion: From this study, we got information about thedemography and prevalence of CIN among VIA positive casesat the same time management of CIN to prevent invasivecervical cancer. We adopted ‘See and treat’ protocol formanagement, which is well accepted, feasible and useful inBangladesh.